Table 2.
Trabecular bone phenotypes of the femurs by microCT analysis
| Group1) | Sex | BMD (mg/cm3) | BV/TV (%) | Tb.Th (μm) | Tb.N (1/mm) | Tb.Sp (μm) | SMI | Conn.D (TV/mm3) |
|---|---|---|---|---|---|---|---|---|
| A | M | 198.9 ± 70.5 | 14.6 ± 2.9 | 37.7 ± 20.2 | 4.4 ± 0.1 | 222.7 ± 6.0 | 2.1 ± 0.8 | 207.5 ± 106.1 |
| A | F | 100.2 ± 13.4 | 5.8 ± 2.5** | 30.6 ± 4.6 | 3.6 ± 0.2** | 277.5 ± 16.0** | 2.7 ± 0.5 | 124.2 ± 54.5 |
| B | M | 246.1 ± 12.2 | 17.8 ± 1.3 | 44.8 ± 7.7 | 5.7 ± 0.5 | 168.4 ± 13.6 | 1.5 ± 0.1 | 378.3 ± 118.0 |
| B | F | 125.0 ± 24.8** | 7.4 ± 2.0** | 33.2 ± 3.1* | 4.0 ± 0.3** | 247.4 ± 22.0** | 2.2 ± 0.3** | 185.1 ± 52.2* |
| D | M | 210.8 ± 62.2 | 14.4 ± 5.7 | 37.9 ± 6.4 | 5.5 ± 0.8 | 178.1 ± 23.5 | 1.6 ± 0.5 | 363.3 ± 132.5 |
| D | F | 150.0 ± 23.6 | 9.0 ± 2.0 | 34.5 ± 1.3 | 4.5 ± 0.4 | 218.6 ± 21.4* | 2.2 ± 0.2 | 241.4 ± 52.6 |
1)
For a description of different groups, see Table 1.
Abbreviations: M, male; F, female; BMD, bone mineral density; BV/TV, relative bone volume; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular separation (marrow thickness); SMI, structure model index; Conn.D, connectivity density.
Values are expressed as mean ± SD. N = 3-5 males and females per group.
*
p< 0.05
**
p < 0.01, compared to the male mice in each group;
No statistical differences are noted in mice in Group B when compared to sex matched mice in Groups A and D.