Figure 2.

Free-energy landscapes of the GluA2 LBD along $\left({\xi }_1,{\xi }_2\right)$. (A) The reaction coordinates used in the REUS simulation. ${\xi }_1$ describes the distance between the COMs of L479-I481 in the D1 lobe and S654-T655 in the D2 lobe. ${\xi }_2$ describes the distance between the COMs of L401-S403 in the D1 lobe and T686-A687 in the D2 lobe. The free-energy landscapes along ${\xi }_1$ and ${\xi }_2$ for flipped (B) and unflipped (C) conformations are shown. White circles represent the corresponding crystal structures. To see this figure in color, go online.