Figure 7.

(A) The chemical structure of a partial agonist, (S)-4-AHCP. (B) The free-energy landscape along ${\xi }_3$ and ${\xi }_4$ for the complex of wild-type (WT) GluA2 and partial agonist (S)-4-AHCP. A white circle and a white triangle represent the corresponding crystal structure and the structure averaged over the semiclosed state, respectively. (C) The superposition of the averaged conformation of the T686A-Glu (magenta) onto that of the WT-(S)-4-AHCP (cyan). The RMSD of two averaged conformations is 0.28 Å. To see this figure in color, go online.