Table 2.
Macroscopic, microscopic and lesion load measures per patient
| Patient ID | Range of macroscopic and microscopic measures within the ROIs | Range of macroscopic measures of the 92 Gy matter regions | Whole brain T2 lesion load (mL) | Brain regions included as ROIs | ||||
|---|---|---|---|---|---|---|---|---|
| Fiber length (mm) | Clustering coefficient | Axonal density (ROD) | Neuronal size (um2) | Fiber length (mm) | Clustering coefficient | |||
| 1 | 123.17 [120.26–126.07] | 0.58 [0.50–0.66] | 0.16 [0.12–0.19] | 102.95 [102.90–103.00] | 134.75 [85.80–231.24] | 0.51 [0.00–1.00] | 28.81 | CG, SFG |
| 2 | 198.23 [178.95–217.51] | 0.11 [0.07–0.14] | 0.27 [0.24–0.30] | 115.54 [112.55–117.92] | 172.16 [112.18–250.10] | 0.09 [0.00–0.52] | 10.84 | SFG, STG |
| 3 | 143.38 [125.78–150.82] | 0.43 [0.39–0.69] | 0.17 [0.12–0.18] | 110.11 [96.71–127.65] | 155.74 [111.13–238.73] | 0.41 [0.00–1.00] | 17.43 | CG, IFG, SFG, STG |
| 4 | 124.48 [114.00–139.55] | 0.62 [0.53–0.70] | 0.17 [0.16–0.19] | 77.22 [62.13–109.91] | 127.19 [81.43–222.68] | 0.53 [0.00–1.00] | 32.10 | CG, IFG, SFG, STG, IPL |
| 5 | 156.78 [124.14–165.22] | 0.43 [0.25–0.50] | 0.17 [0.15–0.19] | 110.33 [95.71–123.32] | 150.49 [92.91–218.917] | 0.33 [0.00–1.00] | 25.45 | CG, IFG, SFG, STG, IPL |
| 6 | 158.78 [129.77–193.72] | 0.57 [0.31–0.66] | 0.24 [0.20–0.26] | 101.79 [99.49–113.65] | 149.86 [98.41–213.48] 171.50 | 0.47 [0.00–1.00] | 16.16 | CG, IFG, SFG, STG, IPL |
| 7 | 145.16 [125.13–169.32] | 0.38 [0.20–0.62] | 0.20 [0.18–0.23] | 115.35 [110.24–124.81] | 153.89 [55.48–225.45] 171.50 | 0.33 [0.00–0.80] | 5.99 | CG, IFG, SFG, STG, IPL |
| 8 | 180.42 [142.50–223.16] | 0.21 [0.07–1.00] | 0.25 [0.22–0.27] | 118.60 [105.85–129.45] | 165.48 [110.22–252.54] | 0.20 [0.00–1.00] | 5.97 | CG, IFG, SFG, STG, IPL |
The median is shown followed by ranges between brackets of fiber length, clustering coefficient, axonal density and neuronal size are presented for the ROIs, per person; the median and ranges are also shown for fiber length and clustering coefficient for the 92 Gy matter regions
ROIs regions of interest, ROD relative optical density, mL milliliter, mm millimeter, CG cingulate gyrus, SFG superior frontal gyrus, STG superior temporal gyrus, IFG inferior frontal gyrus, IPL inferior parietal gyrus