Table 6.
Stratification of EDSS outcome
| EDSS compared to baseline | RRMS n (%) | SPMS n (%) | NMO/NMOSD n (%) |
|---|---|---|---|
| Available scores after 12 months | 66 (p*** ≤ 0.001) | 60 (p*** ≤ 0.001) | 21 (p*** ≤ 0.001) |
| EDSS decreased | 25 (38) | 7 (12) | 6 (29) |
| EDDS stable | 31 (47) | 42 (70) | 12 (57) |
| EDSS increased | 10 (15) | 11 (18) | 3 (14) |
| Available scores after 24 months | 46 (p*** ≤ 0.001) | 39 (p*** ≤ 0.001) | 15 (n.s.) |
| EDSS decreased | 17 (37) | 4 (10) | 4 (17) |
| EDDS stable | 21 (46) | 23 (59) | 6 (40) |
| EDSS increased | 8 (17) | 12 (31) | 5 (33) |
| Available scores after 36 months | 38 (p*** ≤ 0.001) | 29 (p** ≤ 0.01) | 10 (n.s.) |
| EDSS decreased | 14 (37) | 7 (24) | 2 (20) |
| EDDS stable | 17 (45) | 13 (45) | 4 (40) |
| EDSS increased | 7 (18) | 9 (31) | 4 (40) |
The percentage refers to the total number of patients of one subtype at the indicated time point
EDSS Expanded Disability Status Scale, n number of patients, NA data not available, NMO neuromyelitis optica, NMOSD neuromyelitis optica spectrum disease, RRMS relapsing–remitting MS, SPMS secondary progressive MS
p value refers to number of patients with stable disease (= EDDS decreased or stable) and patients with increased EDSS according to course of MS (RRMS, SPMS) or NMO/NMOSD