Table 3.

Univariable and Multivariable Analysis for Coronary Heart Disease Death or Nonfatal Myocardial Infarction Compared With Patients With Normal Coronary Arteries

	Univariable Analysis	p Value	Multivariate Analysis∗	p Value
Nonobstructive disease without adverse plaque†	4.95 (1.34–18.29)	0.016	2.79 (0.64–12.18)	0.172
Nonobstructive disease with adverse plaque†	5.81 (1.50–22.46)	0.011	2.67 (0.53–13.43)	0.234
Obstructive disease without adverse plaque†	7.73 (1.73–34.54)	0.007	3.20 (0.52–19.61)	0.208
Obstructive disease with adverse plaque†	11.50 (3.39–39.04)	<0.001	4.10 (0.76–22.0)	0.100
Coronary artery calcium score‡	1.23 (1.13–1.35)	<0.001	1.12 (0.98–1.28)	0.107
Cardiovascular risk score§	1.65 (1.13–2.41)	0.01	1.10 (0.71–1.70)	0.673

Values are hazard ratio (95% confidence interval). Values in bold indicate statistical significance.

^∗Log rank statistic 27.29, p < 0.001; Harrell’s C-statistic 0.728 (standard error = 0.046).

^†Adverse plaque defined as the presence of positive remodeling or low-attenuation plaque.

^‡Per doubling of coronary artery calcium score.

^§ASSIGN score, per doubling of cardiovascular risk score.