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. 2019 Jan 22;9:32. doi: 10.1038/s41398-018-0358-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The x-axis and y-axis show the methylation levels of M1 and M2 signatures, respectively, which were calculated as the average β values of the top ten CpG sites in each signature. Female and male samples are represented in red and black colors, respectively. The plots are labeled with the associated neuropsychiatric disorders. a Alcohol use disorder, of data set GSE49393. b Schizophrenia, of data set GSE74193 in processing plate “Lieber_289”. c Alzheimer’s disease, of data set GSE80970