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. 2019 Jan 22;9:32. doi: 10.1038/s41398-018-0358-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The x-axis and y-axis show the methylation levels of the M3 and M5 signatures, respectively, which were calculated as the average β values of the top ten CpG sites in each signature. The samples come from the data set GSE41826, which includes methylation data of separated neurons (red), separated glia (green), as well as mixed (black for manually mixed and blue for bulk samples) from healthy human PFC tissues. The proportion of neurons to nonneurons in the empirically mixed samples range from 10 to 90% in 10% increments