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. 2019 Jan 22;9:264. doi: 10.1038/s41598-018-36443-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bioinformatic analysis of circRNA expression pattern during hepatic I/R injury by microarray. (a) Scatter plot analysis was conducted to exhibit the circRNA expression distribution. The green lines represent the default significant fold change (2.0). (b) A volcano graph was created to show significantly dysregulated circRNAs (fold change >2.0, p-value < 0.05). (c) Heat map evaluation of the distinguishable circRNA expression patterns among the normal, I/R, and IPO group samples. Each column represents the expression pattern of one sample, and high and low expression levels are indicated by the “red” and “green” lines, respectively. (d) Venn diagram analysis of dysregulated circRNAs indicated that most of them (51.3% and 58.6%) were sequentially expressed during IPO attenuation of I/R injury.