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. 2019 Jan 22;9:264. doi: 10.1038/s41598-018-36443-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of mmu_circRNA_005186 on LPS-induced inflammation in RAW264.7 cells. (a,b) ELISA assay demonstrated that the supernatant concentrations of TNF-α and IL-1β released from RAW 264.7 cells were significantly lower in the si-005186 group than the negative control. (c) qRT-PCR showed that miR-124-3p was upregulated by 6-fold in the si-005186 group. (d) mmu_circRNA_005186 silencing inhibited the expression level of Epha2 in LPS-induced inflammation. *p < 0.05, **p < 0.01.