Table 2.

Comparison of the computational cost for water models

Model	Cost in core-sec for 10 ps
mW	3.6
ML-BOP	3.8
ML-BOPdih	5.9
ML-mW	2.5
TIP4P/2005	400.0
MB-pol	3213650.0
AMOEBA	1550.0
TIP4P/Ew	410.4
SPC/E	185.6
TIP3P	184.4

The benchmark system is liquid water (256 molecules) at 298 K