Fig. 1. Diagram of CAR T cell treatment process.

The treatment process for patients receiving CAR T cell therapy begins with leukapheresis of the patient’s T cells. Once isolated, autologous T cells are sent for manufacturing to produce genetically modified CAR T cells, which are reprogrammed to facilitate targeted killing of CD19+ B cells. The treatment process is completed with intravenous infusion of CAR T cells back to the patient. CAR chimeric antigen receptor