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. 2019 Jan 22;10(2):54. doi: 10.1038/s41419-019-1318-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — MTT assays were conducted in paclitaxel-sensitive (Ts) MDA-MB 231cells in conditions that enhanced or not tubulin retyrosination (overexpression of the Tubulin Tyrosine Ligase TTL) combined with increased tubulin long-chain polyglutamylation (overexpression of TTLL5 and TTLL11 enzymes) or overexpression of a septin set including SEPT9_i1 or_i3, or both. Each bar is the mean ± s.e.m of at least 10 independent experiments. Statistical analysis is based on the overall comparison of the curves *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. Statistical significance of the comparisons with the negative control is color-coded as indicated. The colors also correspond to the additional percentages of cell survival compared to those of control cells at the IC₅₀: absence of resistance (blue), low level of resistance (light orange, ≤10%), intermediate level (orange, between 10 and 20%) and high level of resistance (red, >20%). The table summarizes the effect (color-coded) of each effector alone or in combination, and indicates the panel(s) displaying the data