Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 22;10:373. doi: 10.1038/s41467-018-08114-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Modelling DNA into the exonuclease site of Pol2_CORE. a The electrostatic surface view of the wild-type exonuclease domain of Pol2_CORE with the modeled position of single stranded DNA (ssDNA) in the exonuclease active site. A representative structure of the ssDNA from our molecular dynamics simulations is shown as sticks (wheat color). b A representative structure of DNA in the wild-type exonuclease domain of Pol2_CORE from the molecular dynamics simulation in cartoon view. The 3´-end of the ssDNA is shown in the front with P301 (in light pink) in the exo-loop on the right hand side. c The crystal structure of P301R overlayed with the ssDNA from (b). The terminal nucleotide (in red) occupies the same space as R301 (the atoms in the guanidine group shown as spheres). d The crystal structure of P301R overlayed with the best representative model from molecular dynamics simulations with wild-type exonuclease domain and ssDNA from (b). The terminal nucleotide (in red) occupies the same space as R301 (with the guanidine group shown as spheres)