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. 2018 Dec 18;120(2):218–228. doi: 10.1038/s41416-018-0347-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Insulin receptor antibodies inhibit angiogenesis in vivo. a CAMs were treated with vaso-occlusive Visudyne^®-photodynamic therapy in the areas indicated with circles. Representative fluorescence angiographies of CAMs before (pre-PDT), 24 and 48 h after PDT are shown. Anti-INSR monoclonal antibody or a polyclonal antibody were administered topically immediately after irradiation, where indicated. The antibody treatment was repeated 24 h later. Angiogenesis in the irradiated zone was imaged 48 h after start of treatment. b Images were quantified using ImageJ software, and quantification using the branching points descriptor is shown. Right images show the concentric circles indicating the 4 treatment areas, and the skeletonised plot of the vasculature. Scale bar represents 200 μm. *P < 0.05, **P < 0.01 by ANOVA with Bonferroni’s Multiple Comparison test, N = 3