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. 2019 Jan 22;9:434. doi: 10.1038/s41598-019-38700-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Change in current due to change in pH. Fit is linear with a slope of −3.2% per pH unit. (b) Change in current due to change in ionic strength, when pH is held constant. Fit is linear with a slope of 3.0% per molar unit of NaCl. (c) Change in slope (dI/dVg) due to change in pH. Fit is linear with a slope of 5.9% per pH unit. (d) Change in slope due to change in ionic strength. Response is fit to −0.3 $\sqrt{[N a C l]}$ . Each datapoint in this figure is an average of data from four sensor chips.