Fig. 6.

sAAV-Tmc1 improves breeding, survival and growth in Tmc1^∆/∆;Tmc2^∆/∆ mice. a Mean ± S.D. birth rate for litters produced by four wild-type C57BL/6 breeding pairs (black), five uninjected Tmc1^∆/∆;Tmc2^∆/∆ breeding pairs (red) and six Tmc1^∆/∆;Tmc2^∆/∆ breeding pairs injected with sAAV-Tmc1 (green). Birth rate was calculated for each breeding pair based on number of litters divided by duration mated. b Litter survival rates wild-type (black), uninjected Tmc1^∆/∆;Tmc2^∆/∆ mice (red), and Tmc1^∆/∆;Tmc2^∆/∆ parents injected with sAAV-Tmc1 (green). Number of litters that survived to wean age (P21) over number produced at P0 are shown above each bar. Litters were classified as non-survival if none of the pups from the litter survived to P21. c Mean ± S.D. mouse weights were taken for uninjected Tmc1^∆/∆;Tmc2^∆/∆ mice (red), uninjected Tmc1^∆/∆;Tmc2^∆/∆ mice whose Tmc1^∆/∆;Tmc2^∆/∆ parents were injected with sAAV-Tmc1 (blue), Tmc1^∆/∆;Tmc2^∆/∆ mice injected on P1 with sAAV-Tmc1 whose parents were also Tmc1^∆/∆;Tmc2^∆/∆ mice injected on P1 with sAAV-Tmc1 (green), and C57BL6/J controls for comparison (black) at 4, 8, and 12 weeks of age as indicated