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. 2019 Jan 22;9:267. doi: 10.1038/s41598-018-36449-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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On-rate measurements. (A) The binding probabilities (P) of TIM-1–EBOV GP/VSV and TIM-4–EBOV GP/VSV interactions are plotted as a function of the contact time (t). The solid line is the result of least-squares fits of equation P = A(1 − (1−exp(−(t − t₀)/τ)), where A and t₀ are the maximal observed binding probability and the shortest contact time tested, respectively. The binding time constant is τ. Equation k_on = 1/(τC_eff) was used to estimation the on-rates. (B) Unbinding force distributions of TIM-1–EBOV GP/VSV (upper panel) and TIM-4–EBOV GP/VSV (lower panel) interactions at 430 ms contact time. Multiple-peak Gaussians were fitted to the curves. Each Gaussian peak and the sum of fitted Gaussians are overlaid on the distribution curve.