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. 2019 Jan 22;9:295. doi: 10.1038/s41598-018-36576-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of relative values of Egr-1 activation at various concentrations of crocetin in vitro. (a) The assay of crocetin was repeated with various concentrations. Note that a statistically significant increase of Egr-1 activation was observed at least with 0.008 mg/ml. *p < 0.05. Bars represent mean +/− standard deviations. (b) Log-linear analysis revealed a significant linear correlation between the concentration of crocetin and the relative value of Egr-1 activation compared to control. X-axis is negative common logarithm of crocetin concentration in DMSO (mg/ml).