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. 2019 Jan 22;9:263. doi: 10.1038/s41598-018-36401-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proximity distributions show that 3D clustered cancer mutations are closer to functional sites than unfiltered mutations. For known functional sites (CSA, Ligand or PPI) 3D clustered mutations are closer than unfiltered mutations from either oncogenes or TSGs. For highly conserved residues in FunFam multiple sequence alignments highly enriched in known functional sites (FunSites), clustered mutations are significantly closer than unfiltered oncogene cancer mutations (there were too few distances measured to plot distributions for FunSites/TSGs). All distributions use UniProt neutral as a control.