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. 2019 Jan 22;9:246. doi: 10.1038/s41598-018-36265-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between placental mTORC1 functional readouts and protein expression of mitochondrial ETC complex I. (a) Protein expression of mitochondrial electron transport chain complexes in placental homogenates of control and IUGR group. Representative Full length Western blot is shown. (b) Relative expression of mitochondrial electron transport chain complex I expression in placental homogenates of control and IUGR. After normalization to β-actin, the mean density of C samples was assigned an arbitrary value of 1. Subsequently, individual IUGR density values were expressed relative to this mean. (c–e) Correlation between placental mTORC1 functional readouts S6K^T-389 (c), 4E-BP1 ^T-37/46 (d) 4E-BP1 (e) and mitochondrial ETC complex I expression. r = Pearson correlation coefficient, n = Control, 19; IUGR, 25. Values are given as means ± S.E.M.; *P < 0.05 vs. control; unpaired Student’s t test.