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. 2019 Jan 22;10(2):56. doi: 10.1038/s41419-018-1296-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Heat-map illustrating the increase (red) and decrease (blue) in expression (log2-fold change) of various cancer-associated genes in EµMyc/Casp2^−/− tumors. b Gene Ontology annotation analysis of the top 20 significantly enriched biological processes (Benjamini adjusted P < 0.05), associated with the genes listed in (a), that show changes in gene expression (FDR < 0.1) (n = 147). The number of genes associated with each biological process is indicated. Complete gene ontology lists are provided in Supplementary Table S8c. c Pathway enrichment analysis (KEGG and REACTOME), of the cancer-associated genes differentially expressed in EµMyc/Casp2^−/− tumors (n = 147). The top 20 enriched pathways are shown. Complete enriched pathway lists are provided in Supplementary Table S8d. The genes associated with each pathway are indicated. Dotted line indicates significance cut off (-log10(P-value), Benjamini corrected)