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. 2019 Jan 22;9:307. doi: 10.1038/s41598-018-36425-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-181a and PER3 are regulated in a circadian manner in BM-MSCs. (A) Diagram depicting the process of cell synchronization and induction of circadian oscillation using glucocorticoid stimulation. (B) Graph depicting the antiphase circadian expression patterns of miR-181a and PER3 in Scp-1 p000 cells. (C) Graph depicting the antiphase circadian expression patterns of miR-181a and PER3 in Scp-1 p181a cells. (D) Graphs depicting the amplitude changes in circadian expression patterns of PER3 and PPARG in the Scp-1 p181a vs p000 cells. (E) Quantification of the amplitude changes in PPARG and PER3 in the Scp-1 p181a vs p000 cells. (F) Graphs depicting the phase shift changes in circadian expression patterns of PER3 and PPARG in the Scp-1 p181a vs p000 cells. (G) Quantification of the phase-shift changes in PPARG and PER3 in the Scp-1 p181a vs p000 cells. Data are representative of 3 independent experiments. * is p ≤ 0.05, ** is p ≤ 0.005, *** is p ≤ 0.0005.