Fig. 6. Fear conditioned behaviors in SERT^+/- rats following 5-HT_1A receptor agonist injections in the BLA.

Line graph represents the mean duration of freezing of SERT^+/− (n = 4) rats with bilateral injections of either artificial cerebral spinal fluid vehicle (n = 5) or the 5-HT_1A receptor agonist 8-OH-DPAT into the BLA prior to (a) acquisition of conditioning with 5 tones followed by 5 mild shocks on day 1; (b) evidence of consolidation on day 2 with initial tone and no shock and extinction learning with subsequent tones and no shock. * and # indicates significant between subjects effects with a Fishers LSD posthoc test or within subject differences over time with a Dunnett’s test (versus tone one, baseline) protected by a repeated measures one way ANOVA. (c) Coronal illustration of a Standard stereotaxic atlas of the rat brain with green circle and green square symbols indicating injection cannula for SERT^+/− rats injected with either vehicle or 8-OH-DPAT, respectively. Error bars represent the SEM