Table 2.

Univariate and multivariable predictors of LGE progression (ΔLGE ≥ 4.75g)

	OR	95% CI	P-value
Univariate analysis
Age at CMR1	1.01	0.97–1.06	0.70
Max LV wall thickness at CMR1	1.25	1.10–1.42	0.001
LV mass at CMR1	1.01	1.01–1.03	0.005
LGE mass at CMR1	1.13	1.06–1.21	<0.001
LVEF at CMR1	0.94	0.86–1.02	0.13
Interval between CMR1-CMR2 (days)	1	1.00–1.01	0.50
Genotypea	1.93	0.55–6.73	0.30
Apical vs. non-apical hypertrophy	1.44	0.24–8.59	0.68
Baseline SCD risk (0 or ≥1)	0.47	0.15–1.48	0.19
Multivariable analysis
Age at CMR1	1.01	0.95–1.07	0.76
Max LVWT at CMR1	1.14	0.96–1.34	0.14
LV mass at CMR1	0.99	0.99–1.01	0.94
LGE mass at CMR1	1.10	1.02–1.19	0.02

CI, confidence interval; CMR, cardiac magnetic resonance imaging; EF, ejection fraction; LGE, late gadolinium enhancement; LV, left ventricular; LVWT, left ventricular wall thickness; OR, odds ratio; SCD, sudden cardiac death.

^aSarcomeric and mitochondrial mutations vs. genotype negative.