Table 3.

Univariate and multivariable Cox regression analysis of predictors of clinical outcomes in HCM

	HR	95% CI	P-value
Univariate Cox
Age at outcome	0.98	0.95–1.01	0.36
Gender	0.83	0.36–1.91	0.66
Maximum LVWT at CMR1	1.10	1.03–1.17	0.007
LV mass at CMR1	1.01	0.99–1.01	0.12
LGE mass at CMR1	1.04	1.01–1.07	0.002
LGE Progression ≥4.75 g	5.53	2.39–12.78	<0.001
Interval between CMR1-CMR2 (days)	1.00	0.99–1.00	0.39
LVEF CMR1	1.01	0.94–1.08	0.85
Apical vs. non-apical hypertrophy	2.21	0.63–7.33	0.22
Genotypea	1.94	0.66–5.69	0.23
Baseline SCD risk factors	0.51	0.21–1.25	0.14
Multivariable Cox
Age at outcome	0.98	0.94–1.01	0.19
Maximum LVWT at CMR1	1.07	0.96–1.19	0.25
LGE mass at CMR1	0.98	0.94–1.03	0.52
LGE Progression ≥4.75 g	5.04	1.85–13.79	0.002

CI, confidence interval; CMR, cardiac magnetic resonance imaging; HR, hazard ratio; LVEF, left ventricular ejection fraction; LVWT, left ventricular wall thickness; SCD, sudden cardiac death.

^aSarcomeric and mitochondrial mutations vs. genotype negative.