Table 2.
Pharmacokinetic parameters of simvastatin and its active metabolite, simvastatin acid, after a single oral administration of simvastatin 40 mg alone and in combination with multiple doses of cilostazol 100 mg in 17 healthy subjects.
| Pharmacokinetic parameter | Simvastatin | Cilostazol + Simvastatin | Geometric least squares mean ratio | |
|---|---|---|---|---|
| Point estimate | 90% CI | |||
| Simvastatin | ||||
| Cmax (μg/L) | 5.84 (69.7) | 10.27 (62.0) | 1.7581 | 1.4167, 2.1819 |
| AUClast (h·μg/L) | 19.97 (78.8) | 34.06 (67.2) | 1.7059 | 1.4456, 2.0131 |
| AUCinf (h·μg/L) | 23.15 (76.1) | 38.02 (64.1) | 1.6423 | 1.3812, 1.9527 |
| tmax (h) | 1.5 (0.5, 4.0) | 1.5 (0.5, 4.0) | - | - |
| t1/2 (h) | 3.73 (80.4) | 3.74 (85.4) | - | - |
| Simvastatin acid | ||||
| Cmax (μg/L) | 2.48 (63.4) | 3.92 (58.6) | 1.5840 | 1.3025, 1.9263 |
| AUClast (h·μg/L) | 17.81 (70.5) | 25.62 (62.6) | 1.4389 | 1.2127, 1.7072 |
| AUCinf (h·μg/L) | 23.08 (80.4) | 30.27 (60.0) | 1.3114 | 1.0363, 1.6596 |
| tmax (h) | 4.0 (1.5, 6.0) | 4.0 (2.0, 6.0) | - | - |
| t1/2 (h) | 5.97 (101.3) | 5.39 (57.3) | - | - |
Data are presented as geometric least squares mean (coefficient of variation), except tmax which is presented as median (min, max).