Table 3.
Serum lipid profiles following a single dose of simvastatin alone on days 1 and 2 and in combination with cilostazol on days 6 and 7.
| Variable | Simvastatin | Cilostazol + Simvastatin | ||
|---|---|---|---|---|
| Day 1 | Day 2 | Day 6 | Day 7 | |
| (n = 17) | (n = 17) | (n = 17) | (n = 17) | |
| Total cholesterol (mg/dL) | 164.5 ± 29.5 | 164.8 ± 29.7 | 159.0 ± 27.7 | 157.8 ± 28.8 |
| p-value∗ | - | 1.0000 | 0.6053 | 0.5713 |
| Triglyceride (mg/dL) | 108.5 ± 41.8 | 99.6 ± 25.7 | 82.0 ± 19.6 | 78.2 ± 19.9 |
| p-value | - | 0.8124 | 0.0200 | 0.0126 |
| LDL-cholesterol (mg/dL) | 97.9 ± 27.9 | 99.4 ± 27.7 | 92.1 ± 25.9 | 92.8 ± 27.7 |
| p-value | - | 1.0000 | 0.4967 | 0.7611 |
| HDL-cholesterol (mg/dL) | 50.9 ± 12.5 | 49.6 ± 13.2 | 53.0 ± 12.0 | 53.5 ± 13.9 |
| p-value | - | 1.0000 | 0.7115 | 0.6426 |
Data are presented as arithmetic mean ± standard deviation.
∗p-value of comparison with Day 1 using a mixed effects model with the Bonferroni adjustment.