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. 2019 Jan 24;30(1):79–87. doi: 10.1089/hum.2018.098

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© Dany Perocheau et al. 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Seroprevalence of immunoglobulin (Ig)G and neutralizing antibodies (Nab) against adeno-associated virus (AAV)-LK03, 3B, and 8 in humans. (A) Anti-IgG and Nab seroprevalences against AAV-LK03; (B) anti-IgG titers against AAV-LK03; (C) Nab seroprevalence against AAV-LK03 according to age; (D) Nab titers against AAV-LK03 according to age; (E) comparison of Nab seroprevalence against AAV-LK03, 3B, and 8; (F) comparison of Nab titers against AAV-LK03, 3B, and 8; (G) Nab seroprevalence according to sex; (H) cross-reactivity of Nab between serotypes. Vertical bars represent the mean. Box-and-whisker plots represent the minimum, the mean, the maximum, and the 25th and 75th percentiles. Samples: (A, B) IgG seroprevalence against AAV-LK03, n = 189; (C–F) Nab seroprevalence against AAV-LK03, n = 323; (E, F) against AAV3B and AAV8, n = 129; (G) male and female samples, n = 50 and n = 77, respectively; (H) n = 49.