Table 6.

LV mRNA expression of markers of hypertrophy and fibrosis

Gene	HF (4), fold control	HF + UCn3 (4), fold control	p
α-MHC	0.5 ± 0.1	0.6 ± 0.1	0.40
β-MHC	25 ± 5	6.6 ± 0.5	0.01
α-skeletal actin	5.3 ± 1	2.3 ± 0.3	0.02
ANF	15 ± 3.8	5.6 ± 0.6	0.05
BNP	3.4 ± 0.4	1.6 ± 0.2	0.006
CARP	3.5 ± 0.3	2.3 ± 0.04	0.01
FHL-1	1.3 ± 0.2	1.6 ± 0.1	0.16
Col1	3.8 ± 0.7	2.7 ± 0.2	0.21
Col3	3.8 ± 0.6	3.0 ± 0.3	0.30
MMP8	0.4 ± 0.1	0.5 ± 0.2	0.89
MMP9	0.4 ± 0.1	0.4 ± 0.1	0.74
TIMP1	0.7 ± 0.01	0.7 ± 0.1	0.46
IL-1b	0.4 ± 0.02	0.4 ± 0.1	0.89
IL-6	3.9 ± 0.4	4 ± 1.3	0.93
IL-10	0.8 ± 0.1	1.2 ± 0.3	0.17

Data are mean ± SE. p-Values are from a Student's t-test (unpaired, two-tailed); numbers in parentheses indicate group size.

Col1, collagen 1; col3, Collagen 3; MMP8, matrix metalloproteinase 8; MMP9, matrix metalloproteinase 9; IL-1b, interleukin 1b; IL-6, interleukin 6; IL-10, interleukin 10.