FIG. 1.
SIV-infection induces a proinflammatory plasma and BALF environment. Monocyte and macrophage-associated cytokines and chemokines were quantified in (A) plasma and (B) BALF. While (A1) MCP-1/CCL2 and (A2) MDC/CCL22 only increased in plasma in chronic SIV-infection, levels of IP-10/CXCL10 increased in both plasma (A3) and BALF (B4). RANTES/CCL5 (B1), MIP-1β/CCL4 (B2), and MIG/CXCL9 (B3) significantly increased in BALF, but not in plasma. Full cytokine/chemokine analyses of this cohort are reported elsewhere.48 BALF, bronchoalveolar lavage fluid; SIV, Simian immunodeficiency virus.