Figure 1.

A, Experimental design. Animals were subjected to swim stress for 10 consecutive days. All animals were checked for regular cycling by analysis of smears during the protocol and killed 60 days after surgery, with a smear at the time of killing. B, Stress increases anxiety levels. Both the sham-stress and endo-stress groups had increased fecal pellet counts compared to endo-no stress or normal indicating increased anxiety levels (n = 10-11 [SEM]; *P <.05, **P <.01, ***P <.001 vs endo-no stress or normal). C, Stress increases implant severity. None of the normal or sham-stress animals developed vesicles. All of the endo animals developed vesicles in at least one of the implant sites. The endo-stress animals had significantly bigger vesicles (n = 10-11 [SEM]; *P <.05). SEM indicates standard error of the mean.