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. 2017 Dec 14;25(3):320–328. doi: 10.1177/1933719117746764

Figure 2.

Figure 2.

Expression of heart- and neural crest derivatives-expressed protein 2 (HAND2) in human endometrial biopsies exposed to ulipristal acetate contraceptive vaginal ring (UPA-CVR) for 24 weeks. Immunohistochemical localization of HAND2 in endometrial sections before and after exposure to UPA-CVR. A total of 12 independent participants were analyzed, and for each participant, 4 endometrial biopsy samples were obtained (N = 48). Panel A represents endometrial specimen obtained during the luteal phase before administration of UPA-CVR. Panels B and C indicate endometrial specimens obtained after each 12-week period with UPA-CVR releasing 1.5 or 2.5 mg UPA daily. Panel D represents endometrial specimen collected during the luteal phase following a posttreatment recovery period. Panel E shows endometrial sections from a biopsy sample after a 12-week exposure to UPA-CVR and subjected to immunohistochemistry (IHC) protocol omitting the primary antibody. Red staining indicates positive staining for HAND2 in endometrial sections. Representative images are shown. S and E indicate stroma and epithelium, respectively. UPA-CVR indicates ulipristal acetate contraceptive vaginal ring; IHC, immunohistochemistry.