Table 2.
Markers of Vitamin D Status and Inflammation in Pregnant Adolescents and Their Neonates at Birth.
| N | Midgestation | N | Delivery | N | Cord | |
|---|---|---|---|---|---|---|
| 25(OH)D, ng/mLa | 155 | 20.2 (18.8-21.8) | 133 | 18.6 (17.0-20.5) | 121 | 18.8 (17.1-20.5) |
| <10 ng/mL, % | 6 | 11 | 13 | |||
| <20 ng/mL, % | 50 | 48 | 47 | |||
| <30 ng/mL, % | 81 | 81 | 81 | |||
| 1,25(OH)2D, pg/mLa | 100 | 117 (111-123)c | 96 | 106 (100-112)d | 74 | 44.7 (41.3-48.4)e |
| iPTH, pg/mLa | 91 | 25.0 (22.3-27.9)c | 80 | 38.4 (33.8-43.6)d | 33 | 19.0 (14.7-23.3)e |
| >65 pg/mL, % | 3.3 | 18 | 0 | |||
| IL-10, pg/mLa | 144 | 4.57 (3.18-6.57)c | 125 | 9.65 (7.22-12.9)d | 96 | 18.0 (13.6-24.0)e |
| ≤0.13 pg/mL, % | 17.4 | 5.6 | 3.1 | |||
| TNF-α, pg/mLa | 145 | 4.48 (3.92-5.14)c | 126 | 3.54 (3.17-3.97)d | 97 | 8.31 (7.40-9.33)e |
| ≤0.13 pg/mL, % | 0.7 | 0 | 0 | |||
| IL-6, pg/mLa | 145 | 1.02 (0.78-1.33)c | 126 | 3.73 (3.01-4.63)d | 97 | 8.41 (5.99-11.7)e |
| ≤0.13 pg/mL, % | 15 | 2.4 | 0 | |||
| CRP, mg/Lb | 113 | 3.78 (3.10-4.66)c | 4 | 2.19 (0.06-79.4) | 86 | 0.17 (0.13-0.23)d |
| ≤0.20 mg/L, % | 0.9 | 25 | 79 | |||
| Hepcidin, ng/mLa | 145 | 20.7 (18.0-23.7)c | 129 | 24.2 (20.2-29.1)c | 120 | 94.2 (80.4-110)d |
| ≤5.0 ng/mL, % | 4.8 | 7.8 | 0 | |||
| Leptin, µg/La | 141 | 22.3 (19.7-25.2)c | 127 | 29.4 (25.7-33.6)d | 114 | 7.47 (6.26-8.91)e |
Abbreviations: 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)2D, 1,25-dihydroxyvitamin D; iPTH, intact parathyroid hormone, IL, interleukin; TNF, tumor necrosis factor; CRP, C-reactive protein; CI, confidence interval.
aValues are presented as either mean or geometric mean (95% CI).
bOnly 4 patients had CRP values at delivery, and these data were excluded from all analyses due to insufficient sample size. Letter superscripts indicate statistically significant differences between mean mid-gestation, delivery, and cord values (P ≤ .05).