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. 2019 Jan 18;8:F1000 Faculty Rev-72. [Version 1] doi: 10.12688/f1000research.16793.1

Figure 2. Epigenetic reprogramming for intestinal homeostasis and regeneration.

Figure 2.

During homeostasis, intestinal stem cells (ISCs) adopt a unique epigenetic signature and chromatin accessibility that collaboratively lead to expression of ISC-related genes and shutdown of lineage-specific factors. Lineage specification of ISCs is accompanied by epigenetic remodeling and chromatin accessibility changes that turn off ISCs genes while activating lineage-restricted genes. During the regenerative process, epigenetic landscape and chromatin accessibility are reconfigured to resemble ISCs during dedifferentiation of ISC progenies.