Table 2.
Multilevel modelling of changes in score from baseline to 12 month follow-up for remote cognitive behavioural therapy (RCBT) intervention versus treatment as usual (TAU)
| RCBT | TAU | Comparison | ||||
|---|---|---|---|---|---|---|
| N | Mean change from baseline (95% CI) | N | Mean change from baseline (95% CI) | Difference (95% CI) | P-value | |
| SHAI | ||||||
| 3 months | 53 | –6.08(–7.90 to –4.26) | 48 | –5.97(–7.97 to –3.97) | –0.11(–2.82 to 2.60) | 0.936 |
| 6 months | 56 | –9.48(–11.20 to –7.75) | 56 | –6.67(–8.30 to –5.04) | –2.81(–5.11 to –0.50) | 0.017 |
| 9 months | 46 | –9.58(–11.33 to –7.84) | 50 | –6.78(–8.43 to –5.12) | –2.81(–5.11 to –0.50) | 0.017 |
| 12 months | 47 | –10.60(–12.31 to –8.89) | 47 | –7.79(–9.43 to –6.16) | –2.81(–5.11 to –0.50) | 0.017 |
| GAD 7 | ||||||
| 3 months | 52 | –3.69(–5.09 to –2.28) | 48 | –4.79(–6.17 to –3.41) | 1.10(–0.84 to 3.05) | 0.265 |
| 6 months | 53 | –6.22(–7.62 to –4.82) | 55 | –3.83(–5.21 to –2.44) | –2.39(–4.40 to –0.39) | 0.020 |
| 9 months | 43 | –5.37(–7.05 to –3.69) | 48 | –4.48(–5.97 to –2.99) | –0.89(–3.00 to 1.23) | 0.408 |
| 12 months | 45 | –6.68(–8.14 to –5.21) | 46 | –3.92(–5.40 to –2.45) | –2.75(–4.82 to –0.68) | 0.009 |
| PHQ9 | ||||||
| 3 months | 52 | –3.24(–4.69 to –1.80) | 47 | –3.01(–4.38 to –1.64) | –0.23(–2.15 to 1.68) | 0.812 |
| 6 months | 53 | –4.67(–6.02 to –3.33) | 55 | –3.11(–4.46 to –1.76) | 1.56(–3.45 to 0.33) | 0.105 |
| 9 months | 43 | –4.41(–6.06 to –2.76) | 48 | –3.24(–4.78 to –1.69) | –1.17(–3.18 to 0.83) | 0.250 |
| 12 months | 45 | –5.05(–6.37 to –3.72 | 45 | –2.69(–4.06 to –1.31) | –2.36(–4.22 to –0.50) | 0.013 |
| PHQ15 | ||||||
| 3 months | 52 | –0.35(–1.58 to 0.88) | 48 | –1.68(–3.16 to –0.19) | 1.33(–0.52 to 3.17) | 0.157 |
| 6 months | 54 | –2.95(–4.11 to –1.78) | 55 | –1.62(–2.90 to –0.34) | –1.33(–3.09 to 0.42) | 0.137 |
| 9 months | 45 | –2.62(–4.19 to –1.04) | 49 | –2.20(–3.47 to –0.92) | –0.42(–2.38 to 1.53) | 0.669 |
| 12 months | 46 | –3.33(–4.62 to –2.04) | 47 | –1.77(–2.99 to –0.55) | –1.57(–3.37 to 0.24) | 0.089 |
| EQ5D–5L (VAS) | ||||||
| 3 months | 52 | 8.74 (3.70 to 13.79) | 47 | 2.80(–2.35 to 7.96) | 5.94(–1.22 to 13.11) | 0.103 |
| 6 months | 54 | 13.66 (8.97 to 18.34) | 55 | 11.10 (6.32 to 15.89) | 2.56(–4.03 to 9.14) | 0.446 |
| 9 months | 45 | 10.24 (5.28 to 15.21) | 49 | 2.92 (–2.06 to 7.90) | 7.33(–0.02 to 14.67) | 0.051 |
| 12 months | 46 | 13.80 (8.90 to 18.71) | 47 | 4.25 (–0.87 to 9.37) | 9.56 (2.73 to 16.39) | 0.006 |
| WSAS | ||||||
| 3 months | 51 | –4.45(–6.63 to –2.27) | 48 | –3.36(–5.61 to –1.10) | –1.10(–4.07 to 1.87) | 0.468 |
| 6 months | 53 | –7.52(–9.85 to –5.19) | 55 | –4.89(–7.03 to –2.75) | –2.63(–5.72 to 0.45) | 0.094 |
| 9 months | 44 | –7.31(–9.81 to –4.81) | 56 | –5.77(–8.15 to –3.39) | –1.54(–4.99 to 1.90) | 0.377 |
| 12 months | 45 | –7.89(–10.22 to –5.56) | 56 | –5.40(–7.79 to –3.01) | –2.49(–5.73 to 0.75) | 0.131 |
| RCBT | TAU | Unadjusted difference in change | ||||
| N | Mean (SD) | n | Mean (SD) | Mean (95% CI) (P-value) | ||
| QALYsa at 12 months | 31 | 0.66 (0.22) | 25 | 0.59 (0.31) | 0.07 (0.07 to 0.21) (0.332) | |
aQALYs at 12 months is based on the complete dataset over the 12-month follow-ups