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Diffusion of a visible dye into the spinal cord after round window injection in newborn mice. Time lapse photographs after intracochlear injection of a visible biological dye (blue) demonstrated diffuse spread into the spinal cord over a relatively short time period. The likely route of egress from the cochlea is through a patent cochlear aqueduct. This finding may explain the tail deformities and central nervous system changes seen with high levels of hGDNF expression.
