Table 3.
Associations of rs2915863, rs2569190, rs2569192, and rs2563298 in CD14 gene with AITDs, GD, and HT.
| SNP | Genotype or allele | NC | AITD | P-value | GD | P-value | HT | P-value |
|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | AITD vs. NC | n (%) | GD vs. NC | n (%) | HT vs. NC | ||
| rs2915863 | CC | 225 (31.47) | 258 (30.46) | 0.060 | 153 (29.31) | 0.007 | 105 (32.31) | 0.889 |
| TC | 370 (51.75) | 407 (48.05) | 244 (46.74) | 163 (50.15) | ||||
| TT | 120 (16.78) | 182 (21.49) | 125 (23.95) | 57 (17.54) | ||||
| C | 820 (57.34) | 923 (54.49) | 0.109 | 550 (52.68) | 0.021 | 373 (57.38) | 0.986 | |
| T | 610 (42.66) | 771 (45.51) | 494 (47.32) | 277 (42.62) | ||||
| rs2569190 | AA | 270 (37.76) | 311 (36.72) | 0.109 | 178 (34.10) | 0.038 | 133 (40.92) | 0.358 |
| AG | 353 (49.37) | 395 (46.64) | 250 (47.89) | 145 (44.62) | ||||
| GG | 92 (12.87) | 141 (16.65) | 94 (18.01) | 47 (14.46) | ||||
| A | 893 (62.45) | 1,017 (60.04) | 0.168 | 606 (58.05) | 0.027 | 411 (63.23) | 0.732 | |
| G | 537 (37.55) | 677 (39.96) | 438 (41.95) | 239 (36.77) | ||||
| rs2569192 | GG | 554 (77.48) | 650 (76.74) | 0.929 | 396 (75.86) | 0.775 | 254 (78.15) | 0.784 |
| CG | 155 (21.68) | 189 (22.31) | 122 (23.37) | 67 (20.2) | ||||
| CC | 6 (0.84) | 8 (0.94) | 4 (0.77) | 4 (1.23) | ||||
| G | 1,263 (88.32) | 1,489 (87.90) | 0.716 | 914 (87.55) | 0.559 | 575 (88.46) | 0.927 | |
| C | 167 (11.68) | 205 (12.10) | 130 (12.45) | 75 (11.54) | ||||
| rs2563298 | CC | 552 (77.20) | 649 (76.62) | 0.955 | 396 (75.86) | 0.866 | 253 (77.85) | 0.695 |
| AC | 158 (22.10) | 190 (22.43) | 122 (23.37) | 68 (20.92) | ||||
| AA | 5 (0.70) | 8 (0.94) | 4 (0.77) | 4 (1.23) | ||||
| C | 1,262 (88.25) | 1,488 (87.84) | 0.841 | 914 (87.55) | 0.675 | 574 (88.31) | 0.846 | |
| A | 168 (11.75) | 206 (12.16) | 130 (12.45) | 76 (11.69) |
AITDs, autoimmune thyroid diseases; GD, Graves' disease; HT, Hashimoto's thyroiditis; NC, Normal Controls. Bold represents a positive P value.