Table 4.
Associations of rs2915863 and rs2569190 in CD14 gene with female GD patients and GD patients with family history.
| SNP | Genotype or allele | NC | Female GD patients | P-value | GD with family history | P-value |
|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | ||||
| rs2915863 | CC | 225 (31.47) | 108 (29.75) | 0.005 | 25 (23.15) | 0.024 |
| TC | 370 (51.75) | 164 (45.18) | 54 (50.00) | |||
| TT | 120 (16.78) | 91 (25.07) | 29 (26.85) | |||
| C | 820 (57.34) | 307 (42.29) | 0.000 | 104 (48.15) | 0.011 | |
| T | 610 (42.66) | 419 (57.71) | 112 (51.85) | |||
| rs2569190 | AA | 270 (37.76) | 119 (32.78) | 0.026 | 29 (26.85) | 0.011 |
| AG | 353 (49.37) | 176 (48.48) | 55 (50.93) | |||
| GG | 92 (12.87) | 68 (18.73) | 24 (22.22) | |||
| A | 893 (62.45) | 414 (57.02) | 0.015 | 113 (52.31) | 0.004 | |
| G | 537 (37.55) | 312 (42.98) | 103 (47.69) |
AITDs, autoimmune thyroid diseases; GD, Graves' disease; HT, Hashimoto's thyroiditis; NC, Normal Controls.