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. 2019 Jan 16;9:3190. doi: 10.3389/fimmu.2018.03190

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Copyright © 2019 Chen, Xiao, Li, Xiao, Xiong, Liu, Wang, Ji, Zhao, Shen, Lu, Fan and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LppZ induces high cellular responsiveness in TB patients. (A) The numbers of IFN-γ producing cells in TB patients (including initial TB patients and retreated TB patients) and HCs were assessed by ELISpot assay after stimulation with E6C10 fusion protein or purified LppZ protein. PHA served as a positive control. (B) Correlation analyses between LppZ- and E6C10-specific IFN-γ producing cells. (C,D) ROC curve analyses of LppZ- (C) and E6C10-specific (D) IFN-γ-producing cells in distinguishing TB patients and HCs. ***p < 0.0001.