Table 3.
Associations between increasing knee joint effusion volume (per 5 ml) from baseline to 1 year and joint outcomes
| Unadjusted analysis | Adjusted analysis | |||
|---|---|---|---|---|
| Regression coefficient (95% CI) | P-value | Regression coefficient (95% CI) | P-value | |
| Annual % medial cartilage volume lossa | 0.02 (−0.04, 0.07) | 0.51 | 0.09 (0.04, 0.15) | 0.001 |
| Annual % lateral cartilage volume lossa | −0.03 (−0.08, 0.01) | 0.11 | 0.04 (−0.01, 0.08) | 0.10 |
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Progression of radiographic OA over 4 years | ||||
| For KL grade 0–3b | 1.13 (1.02, 1.25) | 0.02 | 1.21 (1.11, 1.33) | <0.001 |
| For KL grade 0a | 1.45 (1.10, 1.91) | 0.01 | 1.45 (1.12, 1.88) | 0.004 |
| For KL grade 1a | 1.30 (1.03, 1.65) | 0.03 | 1.38 (1.04, 1.83) | 0.03 |
| For KL grade 2a | 1.04 (0.88, 1.23) | 0.65 | 1.10 (0.94, 1.28) | 0.23 |
| For KL grade 3a | 1.04 (0.89, 1.21) | 0.62 | 1.20 (1.02, 1.41) | 0.03 |
| Total knee replacement over 6 years | ||||
| For KL grade 2–4b | 1.15 (1.03, 1.28) | 0.01 | 1.24 (1.12, 1.37) | <0.001 |
| For KL grade 2a | 1.00 (0.74, 1.37) | 0.98 | 1.09 (0.87, 1.37) | 0.46 |
| For KL grade 3a | 1.28 (1.08, 1.51) | 0.005 | 1.32 (1.12, 1.56) | 0.001 |
| For KL grade 4a | 1.16 (0.99, 1.37) | 0.07 | 1.21 (1.02, 1.44) | 0.03 |
a
Multivariable models adjusted for gender, baseline age, BMI, effusion volume, intra-articular steroid injection, knee injury and intra-articular steroid injection and knee injury at 1 year.
b
Multivariable models adjusted for gender, baseline age, BMI, KL grade, effusion volume, intra-articular steroid injection, knee injury and intra-articular steroid injection and knee injury at 1 year.