Table IV.
Associations of early pregnancy bisphenol and phthalate urine concentrations with gestational hypertensive disorders.
| Gestational hypertension, OR (95% CI) (n = 40) | Pre-eclampsia, OR (95% CI) (n = 24) | |||
|---|---|---|---|---|
| Basic model | Adjusted model | Basic model | Adjusted model | |
| Total bisphenols | 1.05 (0.81, 1.36) | 1.03 (0.78, 1.35) | 1.20 (0.87, 1.66) | 1.14 (0.81, 1.61) |
| Bisphenol A | 1.03 (0.83, 1.27) | 1.02 (0.82, 1.26) | 1.22 (0.94, 1.59) | 1.16 (0.88, 1.53) |
| Bisphenol S | 1.04 (0.86, 1.34) | 1.03 (0.85, 1.26) | 1.05 (0.83, 1.34) | 1.02 (0.80, 1.31) |
| Phthalic acid | 1.05 (0.78, 1.41) | 0.97 (0.71, 1.31) | 1.30 (0.90, 1.86) | 1.19 (0.81, 1.73) |
| LMW phthalate metabolites | 1.12 (0.89, 1.42) | 1.10 (0.86, 1.40) | 1.01 (0.75, 1.36) | 0.95 (0.70, 1.30) |
| HMW phthalate metabolites | 1.03 (0.74, 1.43) | 1.02 (0.72, 1.44) | 1.00 (0.66, 1.52) | 0.92 (0.60, 1.42) |
| DEHP metabolites | 1.03 (0.75, 1.42) | 1.03 (0.74, 1.44) | 1.05 (0.70, 1.57) | 0.98 (0.65, 1.49) |
| DNOP metabolites | 0.95 (0.70, 1.30) | 0.98 (0.70, 1.38) | 1.13 (0.76, 1.69) | 1.07 (0.71, 1.62) |
N = 1219. Values are based on basic and multivariable multinomial regression models that reflect OR and 95% CI for gestational hypertensive disorders per log unit increase in urinary Total bisphenols/BPA/BPS/Phthalic acid/LMW/HMW/DEHP/DNOP metabolite concentrations.
Basic models are adjusted for creatinine. Adjusted models are adjusted for maternal age, maternal pre-pregnancy BMI, parity, ethnicity, education, maternal smoking, maternal alcohol, folic acid supplementation and creatinine.