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. Author manuscript; available in PMC: 2019 Jan 23.
Published in final edited form as: Am J Psychiatry. 2017 Apr 14;174(8):775–784. doi: 10.1176/appi.ajp.2017.16070847

FIGURE 5. Amygdala-Insula Connectivity on a Dot-Probe Task Related to Overall Treatment Response in Youths With Pediatric Anxietya.

FIGURE 5.

aWhole brain random-effects analyses controlling for baseline Pediatric Anxiety Rating Scale (PARS) ratings and attention bias modification therapy (ABMT) indicated a condition (congruent, incongruent, neutral)-by-posttreatment PARS ratings interaction for connectivity between the rightamygdala and insula (panel A; the image is displayed in radiological convention [left=right]) (cluster size=1,859 mm3, peak activation=54, 24, 9). To probe the interaction, correlations between posttreatment PARS ratings and conditionwere examined. Panels B–Dare scatterplots between posttreatment PARS rating and congruent (r=0.43, p<0.01), incongruent (r=−0.11, n.s.), and attention bias (incongruent – congruent; r=−0.48, p<0.01) conditions. PPI=psychophysiological interaction.