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. Author manuscript; available in PMC: 2019 Jan 23.
Published in final edited form as: ACS Chem Biol. 2018 Aug 27;13(9):2708–2718. doi: 10.1021/acschembio.8b00646

Figure 1. Structures of pentamidine analogs.

Figure 1.

a) Heptamidine and b) furamidine have the characteristic structural features of diamidines that bind the minor groove of DNA: the ability to adopt a semi-curved shape, two terminal amidine groups that are positively charged at physiological pH, and a relatively flat conformation.