Table 4.
SN | Compound | Activity | Purpose | Producing strains/Gene cluster | Heterologous host | References |
---|---|---|---|---|---|---|
1 | Abyssomicins 2 and 4 | Anti-HIV | GI/OP | Streptomyces koyangensis SCSIO5802 | S. coelicolor | Tu et al., 2018 |
2 | Albusnodin | - | CA | S. albus DSM 41398 | S. coelicolor | Zong et al., 2018 |
3 | Ammosamides A-C | - | GI/CA | S. sp. CNR-698 | S. coelicolor | Jordan and Moore, 2016 |
4 | Anthracimycin | Anti-MRSA | OP | S. sp. CNH365, S. sp. T676 | S. coelicolor | Alt and Wilkinson, 2015 |
5 | Bottromycins | Antibacterial | GC/NM/OP | S. sp. BC16019, S. scabies | S. coelicolor | Hu et al., 2012; Eyles et al., 2018 |
6 | Cacibiocins A and B | Antibacterial | NM/OP | Catenulispora acidiphila* | S. coelicolor | Zettler et al., 2014 |
7 | Caprazamycin analogues | Antibiotic | OP | S. sp. MK730-62F2 | S. coelicolor | Flinspach et al., 2010 |
8 | Clorobiocin | Gyrase B inhibitor | OP | S. roseochromogenes subsp. oscitans | S. coelicolor | Flinspach et al., 2010 |
9 | Cosmomycin | Antitumor | GI/CA | Streptomyces sp. CNT-302 | S. coelicolor | Larson et al., 2017 |
10 | Coumermycin A1 | Gyrase B inhibitor | OP | S. rishiriensis DSM 40489 | S. coelicolor | Wolpert et al., 2008; Flinspach et al., 2010 |
11 | Desotamides A and B | Antibacterial | OP/GI/NM | S. scopuliridis SCSIO ZJ46 | S. coelicolor | Song et al., 2014; Li et al., 2015 |
12 | Erythreapeptins | Antibacterial | OP | Saccharopolyspora erythraea NRRL 2338* | S. coelicolor | Völler et al., 2012 |
13 | FK506 | Immunosuppressive | OP | S. tsukubaensis NRRL18444 | S. coelicolor | Jones et al., 2013 |
14 | Fluostatin derivatives | - | NM/CA | Micromonospora rosaria SCSION160 | S. coelicolor | Yang et al., 2015 |
15 | GE2270 | Anti-MRSA | Planobispora rosea ATCC 53773* | S. coelicolor | Flinspach et al., 2014 | |
16 | Gougerotin | Antibiotic | GC/NM/OP | S. graminearus* | S. coelicolor | Du et al., 2013; Niu et al., 2013; Wei et al., 2016 |
17 | Intermediates of SPMs, IDMs and LNMs | Antifungal, Anticancer | NM | S. sp. SCSIOI 03032 | S. coelicolor | Ma et al., 2017 |
18 | Kocurin | Anti-MRSA | GI | Kocuria rosea* | S. coelicolor | Linares-Otoya et al., 2017 |
19 | Neoabyssomicins A and B | Anti-HIV | GI/OP | S. koyangensis SCSIO5802 | S. coelicolor | Tu et al., 2018 |
20 | Oviedomycin | Antitumor | CA | S. antibiotics ATCC 11891, S. ansochromogenes | S. coelicolor | Rico et al. 2014; Xu et al., 2017 |
21 | Salinomycin | Antitumor | CA/OP | S. albus DSM41398 | S. coelicolor | Yin et al., 2015 |
22 | Streptocollin | tyrosin phosphatase 1B inhibitor | NM/OP | S. collinus Tü 365 | S. coelicolor | Iftime et al., 2015 |
23 | Streptothricin | Antibiotic | GI/OP | S. sp. fd1-xmd | S. coelicolor | Yu et al., 2018 |
24 | Vancoresmycin | Anti-MRSA, Anti-VRE | OP/GC | Amycolatopsis sp. ST101170 | S. coelicolor | Kepplinger et al., 2018 |
25 | 2-DOS and Paromamine | - | GC | S. kanamyceticus | S. lividans | Nepal et al., 2009 |
26 | 2,4-HMBA | - | GI | S. cremeus NRRL 3241 | S. lividans | Waldman et al., 2015 |
27 | 8-methyl-tetracenomycin C | - | OP | S. lividans | Diaz et al., 2013 | |
28 | Asukamycin | Antitumor | GI/GC | S. nodosus subsp. asukanensis | S. lividans | Rui et al., 2010 |
29 | Avermectins-A2A, B1a and A1a | Anthelmintics | NM | S. avermitillis ATCC 31267 | S. lividans | Deng et al., 2017 |
30 | Blasticidin S derivatives | Fungicides | NM | S. griseochromogenes* | S. lividans | Li et al., 2013b |
31 | Capreomycin | Antitubercolosis | OP | Saccharothrix mutabilis* | S. lividans | Felnagle et al., 2007; Chaudhary et al., 2013 |
32 | Cinnamic acid | Important precursor | OP | Various plants and microorganisms | S. lividans | Xiang and Moore, 2002 |
33 | Cremeomycin | Antitumor | GI/GC | S. cremeus NRRL 3241 | S. lividans | Waldman et al., 2015 |
34 | D-cycloserine | Antituberculosis/anti-anxiety | GI | S. lavendulae ATCC 11924 | S. lividans | Kumagai et al., 2010 |
35 | Dehydrophos | Antibacterial | NM/GI | S. luridus | S. lividans | Circello et al., 2010 |
36 | Hatomarubigin | Antitumor | GI/GC/NM | S. sp. 2238-SVT4 | S. lividans | Izawa et al., 2014 |
37 | Labyrinthopeptins A1 and A2 | Antiviral, antiallodynic | GC/GI/NM | Actinomedura namibiensis* | S. lividans | Krawczyk et al., 2013 |
38 | Leptomycins | Antifungal, antitumor | GI | S. sp. ATCC 39366 | S. lividans | Hu et al., 2005 |
39 | Lipopeptides 8D1-1 and 8D1-2, and streptothricin and borrelidin | Antibacterial | CA/NM | S. rochei | S. lividans | Xu et al., 2016 |
40 | Lyngbyatoxin A and derivatives | Cyanotoxin | NM | Moorea producens* | S. lividans | Zhang et al., 2016a |
41 | Mediomycin A | Antifungal | GI | S. mediocidicus ATCC 23936 | S. lividans | Sun et al., 2018 |
42 | Meridamycin | Neuroprotective | GI/OP | S. sp. NRRL 30748 | S. lividans | Liu et al., 2009 |
43 | Mithramycin A | Anticancer | OP | S. argillaceus ATCC12956 | S. lividans | Novakova et al., 2018 |
44 | Oleandomycin intermediate | Antibiotic | GI/OP | S. antibioticus* | S. lividans | Shah et al., 2000 |
45 | Pacidamycins D and S | Antimicrobial | OP/NM | S. coeruleorubidus | S. lividans | Rackham et al., 2010 |
46 | Pactamides A-F | Antitumor | CA | S. pactum SCSIO 02999 | S. lividans | Saha et al., 2017 |
47 | Platensismycin/Platensin | Antibacterial | GC/GI/NM | S. platensis* | S. lividans | Smanski et al., 2012 |
48 | Ravidomycin | Antitumor | GI | S. ravidus | S. lividans | Kharel et al., 2010 |
49 | Ribostamycin | Anti-immuno deficiency | GI | S. ribosidificus | S. lividans | Subba et al., 2007 |
50 | Terragines A-E | - | NM/MG | Environmental DNA | S. lividans | Wang et al., 2000 |
51 | Thioviridamide | Anticancer | GI | S. olivoviridis NA005001* | S. lividans | Izawa et al., 2013 |
52 | YM-216391 | Antitumor | GI/OP | S. nobilis | S. lividans | Jian et al., 2012 |
53 | A pentacyclic compound | - | MG/NM | Environmental DNA | S. albus | Feng et al., 2011 |
54 | Dithiolopyrrolone | Antibacterial, Antifungal, Insecticidal, Anticancer | OP | S. thioluteus DSM 40027 | S. albus | Zhai et al., 2016 |
55 | Elloramycins | Antitumor | GC/NM | S. olivaceus | S. albus | Patallo et al., 2001 |
56 | Fredericamycin | Antitumor | OP | S. griseus ATCC 49344 | S. albus | Chen et al., 2009 |
57 | Furaquinocins | Antitumor | GI/GC/NM | S. sp. KO-3988 | S. albus | Isogai, et al., 2012 |
58 | Grecocyclines | - | OP | S. sp. Acta 1362 | S. albus | Bilyk et al., 2016 |
59 | Herbicidins | Antibacterial | GI | S. sp. L-9-10 | S. albus | Jung et al., 2006 |
60 | Iso-migrastatin | Anticancer | OP | S. platensis NRRL18993* | S. albus | Yang et al., 2011 |
61 | K252a | GI/GC | Nocardiopisis longicantena JCM 11136 | S. albus | Kim et al., 2007; Chae et al., 2009 | |
62 | KB-346-5 derivative | Anti-MRSA, Anti-VRE | MG | Environmental DNA | S. albus | Feng et al., 2011 |
63 | Kinamycin | Antibiotic | GI/GC | S. galtieri sgt26 | S. albus | Liu et al., 2018 |
64 | Landomycin E | Antibiotic | MG | Environmental DNA | S. albus | Feng et al., 2011 |
65 | Leprotene and derivatives | - | NM/CA | S. argillaceus | S. albus | Becerril et al., 2018 |
66 | Lyngbyatoxin A and derivatives | Neurotoxin | OP | Moorea producens * | S. albus | Zhang et al., 2016a |
67 | Malacidins | Antibacterial, Anti-MRSA | GI/NM/MG | Environmental DNA | S. albus | Hover et al., 2018 |
68 | Moenomycin A | Antibacterial | OP | S. ghanaensis ATCC 14676 | S. albus | Makitrynskyy et al., 2010 |
69 | Myxochelin A | Iron-chelating | NM/MG | Environmental DNA | S. albus | Bitok et al., 2017 |
70 | Pseudoribostamycin | - | NM | S. ribosidificus | S. albus | Subba et al., 2007; Kurumbang et al., 2011 |
71 | Rebeccamycin | Antitumor | OP/NM | Saccharothrix aerocolonigenes ATCC39243 | S. albus | Sánchez et al., 2005 |
72 | Spinosyn | Insecticides | OP | Saccharopolyspora spinose | S. albus | Tan et al., 2017 |
73 | Staurosporine | Antitumor | OP/NM | S. staurosporeus | S. albus | Sánchez et al., 2005 |
74 | Steffimycin and derivatives | Antitumor | OP/NM | S. steffisburgensis NRRL 3193 | S. albus | Gullon et al., 2006; Olano et al., 2008 |
75 | Tetarimycin A | Anti-MRSA | NM | Environmental DNA | S. albus | Bauer et al., 2010; Kallifidas et al., 2012 |
76 | Thiocoraline | Antitumor | NM/OP | Micromonospora sp. ACM2 and M. sp. ML1 | S. albus | Lombó et al., 2006 |
77 | Utahmycins A and B | Anti-MRSA | NM/MG | Environmental DNA | S. albus | Bauer et al., 2010; Kallifidas et al., 2012 |
78 | 4-O-dimethylbarbamide | - | NM/GI | Moorea producens* | S. venezuelae | Kim et al., 2012 |
79 | Gentamicin A2 | Antibiotic | GC | Micromonospora echinospora | S. venezuelae | Park et al., 2008 |
80 | Apigenin | Flavonoid | P | Various plants | S. venezuelae | Park et al., 2010 |
81 | Chrycin | Flavonoid | P | Plant passionflower | S. venezuelae | Park et al., 2010 |
82 | Hopene | - | NM/CA | S. peucetius | S. venezuelae | Ghimire et al., 2015 |
83 | Kanamycins A-D and derivatives | Antibiotic | GI/GC/NM | S. kanamyceticus* | S. venezuelae | Park et al., 2011a |
84 | Naringenin | Flavanone | P | Grapefuit | S. venezuelae | Park et al., 2011b |
85 | Oxykanamycin C | - | NM | S. kanamyceticus/S. spectabilis | S. venezuelae | Nepal et al., 2010 |
86 | Oxytetracycline | Antibacterial | OP | S. rimous M4018 | S. venezuelae | Yin et al., 2016 |
87 | Pinocembrin | Flavanone (antioxidant) | P | Various plants, | S. venezuelae | Park et al., 2011b |
88 | Pinosylvin | Stilbenoid toxin | P | Pinaceae trees | S. venezuelae | Park et al., 2009 |
89 | Pseudoribostamycin | - | NM | S. ribosidificus | S. venezuelae | Kurumbang et al., 2011 |
90 | Resveratrol | Stilbenoid (dietary supplement) | P | Grape and various berries | S. venezuelae | Park et al., 2009 |
91 | Spectinomycin | Antibiotic | GI/GC | S. spectabilis | S. venezuelae | Thapa et al., 2008; Lamichhane et al., 2014 |
92 | Tylosin derivatives | - | NM/OP | S. fradiae ATCC19609 | S. venezuelae | Jung et al., 2007; Jung et al., 2008 |
93 | Abietatriene | - | P | Ginkgo biloba | S. avermitilis | Komatsu et al., 2013 |
94 | Amorpha-1,4-diene | - | P | Artemisia annua | S. avermitilis | Komatsu et al., 2010 |
95 | Aureothin | Antifungal/antibacterial | OP | S. sp. MM3 | S. avermitilis | Komatsu et al., 2013 |
96 | Bafilomycin B1 | Antifungal/anti bacterial | OP | Kitasatospora setae KM-6054 | S. avermitilis | Komatsu et al., 2013 |
97 | Cephamycin C | β-lactam antibiotics | GI/OP | S. clavuligerus | S. avermitilis | Komatsu et al., 2010 |
98 | Chloramphenicol | Antibacterial | OP | S. venezuelae ATCC10712 | S. avermitilis | Komatsu et al., 2013 |
99 | Clavulanic acid | β-lactam antibiotics | GC/OP | S. clavuligerus | S. avermitilis | Komatsu et al., 2013 |
100 | Cyslabdan A and derivatives | Anti-MRSA | GI/NM | S. cyslabdanicus K04-0144 | S. avermitilis | Ikeda et al., 2016 |
101 | Erythromycin | Antibacterial | OP | Sacchropolyspora erythraea NRRL2338 | S. avermitilis | Komatsu et al., 2013 |
102 | Holomycin | Antitumor | OP | S. clavuligerus | S. avermitilis | Komatsu et al., 2013 |
103 | Kasugamycin | Antitumor | OP | S. kasugaensis MB273 | S. avermitilis | Komatsu et al., 2013 |
104 | Lactacystin | - | OP | S. lactacvstinaeus OM-6519 | S. avermitilis | Komatsu et al., 2013 |
105 | Leptomycin | Antifungal | OP | S. sp. EM52 | S. avermitilis | Komatsu et al., 2013 |
106 | Levopimaradine | - | P | Ginkgo biloba | S. avermitilis | Komatsu et al., 2013 |
107 | Lyngbyatoxin A and derivatives | Cyanotoxin | OP/NM | Moorea producens* | S. avermitilis | Zhang et al., 2016a |
108 | Mycosporine-glycineal-anine | Anti-UV | OP | Actinosynnema mirum DSM 43827 | S. avermitilis | Miyamoto et al., 2014 |
109 | Novobiocin | Antibacterial | OP | S. caeruleus NCBI11891 | S. avermitilis | Komatsu et al., 2013 |
110 | Oxytetracycline | Antibacterial | OP | S. rimous | S. avermitilis | Komatsu et al., 2013 |
111 | Pentalenolactone | Antibiotic | GC | S. exfoliatus UC5319, S. arenae TÜ469 | S. avermitilis | Komatsu et al., 2013 |
112 | Pholipomycin | - | OP/GI | S. clavuligerus | S. avermitilis | Komatsu et al., 2013 |
113 | Pladienolide B | Antitumor | GI/OP | S. platensis Mer-11107 | S. avermitilis | Komatsu et al., 2010 |
114 | Porphyra-334 | Anti-UV | OP | Actinosynnema mirum DSM 43827 | S. avermitilis | Miyamoto et al., 2014 |
115 | Raimonol | - | GI | S. anulatus GM95 | S. avermitilis | Ikeda et al., 2016 |
116 | Rebeccamycin | Antitumor | OP | Lechevalieria aerocolonigenes ATCC 39243 | S. avermitilis | Komatsu et al., 2013 |
117 | Resistomycin | Antibiotic | OP/GI | S. sp. NA 97 | S. avermitilis | Komatsu et al., 2013 |
118 | Ribostamycin | Antitumor | OP | S. ribosidificus ATCC21294 | S. avermitilis | Komatsu et al., 2013 |
119 | Shinorine | Anti-UV | OP | Actinosynnema mirum DSM 43827, Pseudonocarida sp. strain P1 | S. avermitilis | Miyamoto et al., 2014 |
120 | Streptomycin | Antibiotic | GI/OP | S. griseus IFO13350 | S. avermitilis | Komatsu et al., 2010 |
121 | Taxa-1,4-diene | - | P | Taxus brevifolia | S. avermitilis | Komatsu et al., 2013 |
122 | Telomestatin and derivatives | Telomerase inhibitor | OP/NM | S. anulatus 3533-SV4 | S. avermitilis | Amagai et al., 2017 |
-, information not available.