Table 4.

Trials and examples of heterologous expression or production of natural products in Streptomyces hosts. CA, Cryptic pathway Activation/awakening; GC, Gene Characterization (individual gene function); GI, Gene cluster Identification; MG, MetaGenomics; NM, New Metabolite; OP, Over-Production; and P, Plant-derived NPs. * stands for genetically intractable organisms.

SN	Compound	Activity	Purpose	Producing strains/Gene cluster	Heterologous host	References
1	Abyssomicins 2 and 4	Anti-HIV	GI/OP	Streptomyces koyangensis SCSIO5802	S. coelicolor	Tu et al., 2018
2	Albusnodin	-	CA	S. albus DSM 41398	S. coelicolor	Zong et al., 2018
3	Ammosamides A-C	-	GI/CA	S. sp. CNR-698	S. coelicolor	Jordan and Moore, 2016
4	Anthracimycin	Anti-MRSA	OP	S. sp. CNH365, S. sp. T676	S. coelicolor	Alt and Wilkinson, 2015
5	Bottromycins	Antibacterial	GC/NM/OP	S. sp. BC16019, S. scabies	S. coelicolor	Hu et al., 2012; Eyles et al., 2018
6	Cacibiocins A and B	Antibacterial	NM/OP	Catenulispora acidiphila*	S. coelicolor	Zettler et al., 2014
7	Caprazamycin analogues	Antibiotic	OP	S. sp. MK730-62F2	S. coelicolor	Flinspach et al., 2010
8	Clorobiocin	Gyrase B inhibitor	OP	S. roseochromogenes subsp. oscitans	S. coelicolor	Flinspach et al., 2010
9	Cosmomycin	Antitumor	GI/CA	Streptomyces sp. CNT-302	S. coelicolor	Larson et al., 2017
10	Coumermycin A1	Gyrase B inhibitor	OP	S. rishiriensis DSM 40489	S. coelicolor	Wolpert et al., 2008; Flinspach et al., 2010
11	Desotamides A and B	Antibacterial	OP/GI/NM	S. scopuliridis SCSIO ZJ46	S. coelicolor	Song et al., 2014; Li et al., 2015
12	Erythreapeptins	Antibacterial	OP	Saccharopolyspora erythraea NRRL 2338*	S. coelicolor	Völler et al., 2012
13	FK506	Immunosuppressive	OP	S. tsukubaensis NRRL18444	S. coelicolor	Jones et al., 2013
14	Fluostatin derivatives	-	NM/CA	Micromonospora rosaria SCSION160	S. coelicolor	Yang et al., 2015
15	GE2270	Anti-MRSA		Planobispora rosea ATCC 53773*	S. coelicolor	Flinspach et al., 2014
16	Gougerotin	Antibiotic	GC/NM/OP	S. graminearus*	S. coelicolor	Du et al., 2013; Niu et al., 2013; Wei et al., 2016
17	Intermediates of SPMs, IDMs and LNMs	Antifungal, Anticancer	NM	S. sp. SCSIOI 03032	S. coelicolor	Ma et al., 2017
18	Kocurin	Anti-MRSA	GI	Kocuria rosea*	S. coelicolor	Linares-Otoya et al., 2017
19	Neoabyssomicins A and B	Anti-HIV	GI/OP	S. koyangensis SCSIO5802	S. coelicolor	Tu et al., 2018
20	Oviedomycin	Antitumor	CA	S. antibiotics ATCC 11891, S. ansochromogenes	S. coelicolor	Rico et al. 2014; Xu et al., 2017
21	Salinomycin	Antitumor	CA/OP	S. albus DSM41398	S. coelicolor	Yin et al., 2015
22	Streptocollin	tyrosin phosphatase 1B inhibitor	NM/OP	S. collinus Tü 365	S. coelicolor	Iftime et al., 2015
23	Streptothricin	Antibiotic	GI/OP	S. sp. fd1-xmd	S. coelicolor	Yu et al., 2018
24	Vancoresmycin	Anti-MRSA, Anti-VRE	OP/GC	Amycolatopsis sp. ST101170	S. coelicolor	Kepplinger et al., 2018
25	2-DOS and Paromamine	-	GC	S. kanamyceticus	S. lividans	Nepal et al., 2009
26	2,4-HMBA	-	GI	S. cremeus NRRL 3241	S. lividans	Waldman et al., 2015
27	8-methyl-tetracenomycin C	-	OP		S. lividans	Diaz et al., 2013
28	Asukamycin	Antitumor	GI/GC	S. nodosus subsp. asukanensis	S. lividans	Rui et al., 2010
29	Avermectins-A2A, B1a and A1a	Anthelmintics	NM	S. avermitillis ATCC 31267	S. lividans	Deng et al., 2017
30	Blasticidin S derivatives	Fungicides	NM	S. griseochromogenes*	S. lividans	Li et al., 2013b
31	Capreomycin	Antitubercolosis	OP	Saccharothrix mutabilis*	S. lividans	Felnagle et al., 2007; Chaudhary et al., 2013
32	Cinnamic acid	Important precursor	OP	Various plants and microorganisms	S. lividans	Xiang and Moore, 2002
33	Cremeomycin	Antitumor	GI/GC	S. cremeus NRRL 3241	S. lividans	Waldman et al., 2015
34	D-cycloserine	Antituberculosis/anti-anxiety	GI	S. lavendulae ATCC 11924	S. lividans	Kumagai et al., 2010
35	Dehydrophos	Antibacterial	NM/GI	S. luridus	S. lividans	Circello et al., 2010
36	Hatomarubigin	Antitumor	GI/GC/NM	S. sp. 2238-SVT4	S. lividans	Izawa et al., 2014
37	Labyrinthopeptins A1 and A2	Antiviral, antiallodynic	GC/GI/NM	Actinomedura namibiensis*	S. lividans	Krawczyk et al., 2013
38	Leptomycins	Antifungal, antitumor	GI	S. sp. ATCC 39366	S. lividans	Hu et al., 2005
39	Lipopeptides 8D1-1 and 8D1-2, and streptothricin and borrelidin	Antibacterial	CA/NM	S. rochei	S. lividans	Xu et al., 2016
40	Lyngbyatoxin A and derivatives	Cyanotoxin	NM	Moorea producens*	S. lividans	Zhang et al., 2016a
41	Mediomycin A	Antifungal	GI	S. mediocidicus ATCC 23936	S. lividans	Sun et al., 2018
42	Meridamycin	Neuroprotective	GI/OP	S. sp. NRRL 30748	S. lividans	Liu et al., 2009
43	Mithramycin A	Anticancer	OP	S. argillaceus ATCC12956	S. lividans	Novakova et al., 2018
44	Oleandomycin intermediate	Antibiotic	GI/OP	S. antibioticus*	S. lividans	Shah et al., 2000
45	Pacidamycins D and S	Antimicrobial	OP/NM	S. coeruleorubidus	S. lividans	Rackham et al., 2010
46	Pactamides A-F	Antitumor	CA	S. pactum SCSIO 02999	S. lividans	Saha et al., 2017
47	Platensismycin/Platensin	Antibacterial	GC/GI/NM	S. platensis*	S. lividans	Smanski et al., 2012
48	Ravidomycin	Antitumor	GI	S. ravidus	S. lividans	Kharel et al., 2010
49	Ribostamycin	Anti-immuno deficiency	GI	S. ribosidificus	S. lividans	Subba et al., 2007
50	Terragines A-E	-	NM/MG	Environmental DNA	S. lividans	Wang et al., 2000
51	Thioviridamide	Anticancer	GI	S. olivoviridis NA005001*	S. lividans	Izawa et al., 2013
52	YM-216391	Antitumor	GI/OP	S. nobilis	S. lividans	Jian et al., 2012
53	A pentacyclic compound	-	MG/NM	Environmental DNA	S. albus	Feng et al., 2011
54	Dithiolopyrrolone	Antibacterial, Antifungal, Insecticidal, Anticancer	OP	S. thioluteus DSM 40027	S. albus	Zhai et al., 2016
55	Elloramycins	Antitumor	GC/NM	S. olivaceus	S. albus	Patallo et al., 2001
56	Fredericamycin	Antitumor	OP	S. griseus ATCC 49344	S. albus	Chen et al., 2009
57	Furaquinocins	Antitumor	GI/GC/NM	S. sp. KO-3988	S. albus	Isogai, et al., 2012
58	Grecocyclines	-	OP	S. sp. Acta 1362	S. albus	Bilyk et al., 2016
59	Herbicidins	Antibacterial	GI	S. sp. L-9-10	S. albus	Jung et al., 2006
60	Iso-migrastatin	Anticancer	OP	S. platensis NRRL18993*	S. albus	Yang et al., 2011
61	K252a	GI/GC		Nocardiopisis longicantena JCM 11136	S. albus	Kim et al., 2007; Chae et al., 2009
62	KB-346-5 derivative	Anti-MRSA, Anti-VRE	MG	Environmental DNA	S. albus	Feng et al., 2011
63	Kinamycin	Antibiotic	GI/GC	S. galtieri sgt26	S. albus	Liu et al., 2018
64	Landomycin E	Antibiotic	MG	Environmental DNA	S. albus	Feng et al., 2011
65	Leprotene and derivatives	-	NM/CA	S. argillaceus	S. albus	Becerril et al., 2018
66	Lyngbyatoxin A and derivatives	Neurotoxin	OP	Moorea producens *	S. albus	Zhang et al., 2016a
67	Malacidins	Antibacterial, Anti-MRSA	GI/NM/MG	Environmental DNA	S. albus	Hover et al., 2018
68	Moenomycin A	Antibacterial	OP	S. ghanaensis ATCC 14676	S. albus	Makitrynskyy et al., 2010
69	Myxochelin A	Iron-chelating	NM/MG	Environmental DNA	S. albus	Bitok et al., 2017
70	Pseudoribostamycin	-	NM	S. ribosidificus	S. albus	Subba et al., 2007; Kurumbang et al., 2011
71	Rebeccamycin	Antitumor	OP/NM	Saccharothrix aerocolonigenes ATCC39243	S. albus	Sánchez et al., 2005
72	Spinosyn	Insecticides	OP	Saccharopolyspora spinose	S. albus	Tan et al., 2017
73	Staurosporine	Antitumor	OP/NM	S. staurosporeus	S. albus	Sánchez et al., 2005
74	Steffimycin and derivatives	Antitumor	OP/NM	S. steffisburgensis NRRL 3193	S. albus	Gullon et al., 2006; Olano et al., 2008
75	Tetarimycin A	Anti-MRSA	NM	Environmental DNA	S. albus	Bauer et al., 2010; Kallifidas et al., 2012
76	Thiocoraline	Antitumor	NM/OP	Micromonospora sp. ACM2 and M. sp. ML1	S. albus	Lombó et al., 2006
77	Utahmycins A and B	Anti-MRSA	NM/MG	Environmental DNA	S. albus	Bauer et al., 2010; Kallifidas et al., 2012
78	4-O-dimethylbarbamide	-	NM/GI	Moorea producens*	S. venezuelae	Kim et al., 2012
79	Gentamicin A2	Antibiotic	GC	Micromonospora echinospora	S. venezuelae	Park et al., 2008
80	Apigenin	Flavonoid	P	Various plants	S. venezuelae	Park et al., 2010
81	Chrycin	Flavonoid	P	Plant passionflower	S. venezuelae	Park et al., 2010
82	Hopene	-	NM/CA	S. peucetius	S. venezuelae	Ghimire et al., 2015
83	Kanamycins A-D and derivatives	Antibiotic	GI/GC/NM	S. kanamyceticus*	S. venezuelae	Park et al., 2011a
84	Naringenin	Flavanone	P	Grapefuit	S. venezuelae	Park et al., 2011b
85	Oxykanamycin C	-	NM	S. kanamyceticus/S. spectabilis	S. venezuelae	Nepal et al., 2010
86	Oxytetracycline	Antibacterial	OP	S. rimous M4018	S. venezuelae	Yin et al., 2016
87	Pinocembrin	Flavanone (antioxidant)	P	Various plants,	S. venezuelae	Park et al., 2011b
88	Pinosylvin	Stilbenoid toxin	P	Pinaceae trees	S. venezuelae	Park et al., 2009
89	Pseudoribostamycin	-	NM	S. ribosidificus	S. venezuelae	Kurumbang et al., 2011
90	Resveratrol	Stilbenoid (dietary supplement)	P	Grape and various berries	S. venezuelae	Park et al., 2009
91	Spectinomycin	Antibiotic	GI/GC	S. spectabilis	S. venezuelae	Thapa et al., 2008; Lamichhane et al., 2014
92	Tylosin derivatives	-	NM/OP	S. fradiae ATCC19609	S. venezuelae	Jung et al., 2007; Jung et al., 2008
93	Abietatriene	-	P	Ginkgo biloba	S. avermitilis	Komatsu et al., 2013
94	Amorpha-1,4-diene	-	P	Artemisia annua	S. avermitilis	Komatsu et al., 2010
95	Aureothin	Antifungal/antibacterial	OP	S. sp. MM3	S. avermitilis	Komatsu et al., 2013
96	Bafilomycin B1	Antifungal/anti bacterial	OP	Kitasatospora setae KM-6054	S. avermitilis	Komatsu et al., 2013
97	Cephamycin C	β-lactam antibiotics	GI/OP	S. clavuligerus	S. avermitilis	Komatsu et al., 2010
98	Chloramphenicol	Antibacterial	OP	S. venezuelae ATCC10712	S. avermitilis	Komatsu et al., 2013
99	Clavulanic acid	β-lactam antibiotics	GC/OP	S. clavuligerus	S. avermitilis	Komatsu et al., 2013
100	Cyslabdan A and derivatives	Anti-MRSA	GI/NM	S. cyslabdanicus K04-0144	S. avermitilis	Ikeda et al., 2016
101	Erythromycin	Antibacterial	OP	Sacchropolyspora erythraea NRRL2338	S. avermitilis	Komatsu et al., 2013
102	Holomycin	Antitumor	OP	S. clavuligerus	S. avermitilis	Komatsu et al., 2013
103	Kasugamycin	Antitumor	OP	S. kasugaensis MB273	S. avermitilis	Komatsu et al., 2013
104	Lactacystin	-	OP	S. lactacvstinaeus OM-6519	S. avermitilis	Komatsu et al., 2013
105	Leptomycin	Antifungal	OP	S. sp. EM52	S. avermitilis	Komatsu et al., 2013
106	Levopimaradine	-	P	Ginkgo biloba	S. avermitilis	Komatsu et al., 2013
107	Lyngbyatoxin A and derivatives	Cyanotoxin	OP/NM	Moorea producens*	S. avermitilis	Zhang et al., 2016a
108	Mycosporine-glycineal-anine	Anti-UV	OP	Actinosynnema mirum DSM 43827	S. avermitilis	Miyamoto et al., 2014
109	Novobiocin	Antibacterial	OP	S. caeruleus NCBI11891	S. avermitilis	Komatsu et al., 2013
110	Oxytetracycline	Antibacterial	OP	S. rimous	S. avermitilis	Komatsu et al., 2013
111	Pentalenolactone	Antibiotic	GC	S. exfoliatus UC5319, S. arenae TÜ469	S. avermitilis	Komatsu et al., 2013
112	Pholipomycin	-	OP/GI	S. clavuligerus	S. avermitilis	Komatsu et al., 2013
113	Pladienolide B	Antitumor	GI/OP	S. platensis Mer-11107	S. avermitilis	Komatsu et al., 2010
114	Porphyra-334	Anti-UV	OP	Actinosynnema mirum DSM 43827	S. avermitilis	Miyamoto et al., 2014
115	Raimonol	-	GI	S. anulatus GM95	S. avermitilis	Ikeda et al., 2016
116	Rebeccamycin	Antitumor	OP	Lechevalieria aerocolonigenes ATCC 39243	S. avermitilis	Komatsu et al., 2013
117	Resistomycin	Antibiotic	OP/GI	S. sp. NA 97	S. avermitilis	Komatsu et al., 2013
118	Ribostamycin	Antitumor	OP	S. ribosidificus ATCC21294	S. avermitilis	Komatsu et al., 2013
119	Shinorine	Anti-UV	OP	Actinosynnema mirum DSM 43827, Pseudonocarida sp. strain P1	S. avermitilis	Miyamoto et al., 2014
120	Streptomycin	Antibiotic	GI/OP	S. griseus IFO13350	S. avermitilis	Komatsu et al., 2010
121	Taxa-1,4-diene	-	P	Taxus brevifolia	S. avermitilis	Komatsu et al., 2013
122	Telomestatin and derivatives	Telomerase inhibitor	OP/NM	S. anulatus 3533-SV4	S. avermitilis	Amagai et al., 2017

-, information not available.