Figure 1.

Cell polarity plays a critical role in cell function. A prime example is the epithelial cells utilizing apical-basal polarity to provide a barrier function against pathogens. Another example is cell migration which requires front-to-back polarity to allow cells to adhere to and detach from the ECM. Polarity is also required for neurons to perform their task of propagating action potentials and sending messages from the central nervous system to distant body parts.