Figure 3. Analysis of Atherosclerosis in Regression.

Atherosclerosis was developed in apoE^−/−mice as described in Materials and Methods. After lethal irradiation, mice underwent BMT from wildtype (WT) or MΦLRP1^−/− mice and switched to chow diet for 10 weeks. ApoE^−/− recipient mice were sacrificed after 2 weeks on chow diet and used as baseline. (A) Total serum cholesterol and (B) total serum triglycerides from apoE^−/− on Western diet for 12 weeks (Before BMT) and from WT and MΦLRP1^−/− recipient mice after 10 weeks on chow diet (mg/dL). (C) and (D) Cross-sections of aortic sinus were obtained and plaque area determined by Oil Red O staining (×10³ μm²). One-way ANOVA with Bonferroni’s post hoc tests were used to compare effects across genotypes.