Table 1.

Summary of mutations and fusion genes involving GTPase and TCR–related genes in peripheral T-cell lymphomas.

Gene	Mutation	Affected domain/Functional consequence	References
VAV1	SNV	Activating	5, 32
	Fusion	Truncation of SH3 domain in VAV1-GSS and VAV1-MYO1F fusions; increased RAC activation	30
RHOA	SNV	G17V in GTP binding domain; dominant negative function	35–37
FYN	SNV	SH2 domain; activating through loss of inhibitory SH2 domain and Y531 interaction	5, 32, 36
CD28	SNV	D124, T195; activation of NF-κB and TCR signaling	32, 48, 49
	Fusion	CTLA4-CD28 and ICOS-CD28	5, 32, 48, 50
LCK	SNV	Predicted activating	5
PLCG1	SNV	MALT1 and NFAT activation	5, 32, 41
KRAS	SNV	Activating	5, 43

SNV, single nucleotide variant; TCR, T-cell receptor.