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. 2018 Oct 11;115(10):2067–2077. doi: 10.1016/j.bpj.2018.10.006

Figure 3.

Figure 3

Rearward bias in Golgi position is specific to the subpopulation of TGFβ-treated cells that exhibits enhanced migration. (a) A log-log plot of migration speed and persistence for untreated cells (Unt; black, n = 49) and TGFβ-treated cells (red, n = 61). Dashed vertical and horizontal lines indicate 90th percentile values of speed and persistence, respectively, among untreated cells. TGFβ-treated cells within demarcated region are nonresponsive (NR, red squares, n = 24), whereas those outside are responsive (R) (red diamonds, n = 37). (b) Mean speed (left) and persistence (right) of R cells are significantly higher than that of NR and Unt cells (∗p < 0.0001 by post hoc Tukey’s test). (c) Odds of finding a cell in state B (Golgi behind) are quantified by the ratio of fraction time spent with the Golgi behind to the fraction time spent with Golgi ahead. One-way ANOVA (analysis of variance) followed by post hoc Tukey’s test shows that the odds of state B for R cells are statistically distinguishable from those for NR cells (∗p < 0.05) and Unt cells (∗∗p < 0.0005), whereas odds of B for Unt and NR cells are statistically indistinguishable (#p > 0.8).