Figure 4.

Potential linkages between elements of RBC storage lesion and reported clinical sequelae of RBC transfusion.

RBC: red blood cell; ATP: adenosine triphosphate (ATP); DPG: diphosphoglycerate; GSH: glutathione; NAD(P)H: nicotinamide adenine dinucleotide phosphate; PS: phosphatidylserine; PE: phosphatidylethanolamine; NTBI: non-transferrin bound iron; INOBA: insufficient nitric oxide bioavailability; TRALI: transfusion-related acute lung injury; TACO: transfusion-associated circulatory overload.